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目的观察小剂量雌孕激素联合使用防治绝经后骨质疏松症的临床疗效。方法对 195例绝经后骨质疏松患者 ,分别采用复方尼尔雌醇 ( 12 3例 )和安慰剂 ( 72例 )对比治疗。观察两组治疗一年后多种生化指标及骨密度等系数的变化。结果治疗组一年前后骨密度差值与对照组比较 ,在前臂处表现有显著性差异 (P <0 .0 5 ) ,即治疗组骨密度较高。在其他部位骨密度虽无显著性差异 (P>0 .0 5 ) ,但均有增加的趋势。其他观察指标如 :肝肾功能 ,乳腺红外线扫描、子宫大小及内膜B超、阴道脱落细胞找癌细胞、阴道流血、骨折等均无显著性差异 (P >0 .0 5 )结论小剂量雌孕激素联合使用具有疗效确切、副作用少、服用方便的优点。
Objective observe the combination of small doses of estrogen and progesterone in the prevention and treatment of postmenopausal osteoporosis clinical efficacy. Methods 195 195 patients with postmenopausal osteoporosis were treated with compound nylestriol (123 cases) and placebo (72 cases). The changes of multiple biochemical indexes and bone mineral density coefficient after one year of treatment in both groups were observed. Results 骨 The difference of BMD in the treatment group one year ago was significantly different from that in the control group (P <0.05), that is, the BMD in the treatment group was higher. There was no significant difference in other parts of bone mineral density (P> 0.05), but both had an increasing trend. Other observational indicators such as liver and kidney function, breast infrared scan, uterine size and endometrial B ultrasound, vaginal exfoliated cells looking for cancer cells, vaginal bleeding, fractures were no significant difference (P> 0.05) Conclusion small The combined use of estrogen and progesterone dose has the advantages of definite curative effect, less side effects and convenient taking.