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maspin是一种肿瘤抑制基因,该基因具有诱导肿瘤细胞凋亡,抑制肿瘤细胞运动、侵袭、转移和肿瘤新生血管生成等作用。maspin基因表达受体内多条途径的精确调控,但其在肝癌中作用的研究较少。该文就maspin基因的抑癌作用机制及其在肝癌中作用的研究进展作一综述。
Maspin is a tumor suppressor gene, which has the functions of inducing tumor cell apoptosis, inhibiting tumor cell motility, invasion, metastasis and tumor angiogenesis. Maspin gene expression is regulated by many pathways in the body, but its role in liver cancer is less studied. This article reviewed the mechanism of maspin antitumor effect and its role in hepatocellular carcinoma.