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目的:探讨自体血回输对外伤性多脏器损伤患者免疫功能指标的影响。方法:以2011-03-2015-09在急诊科接受术中自体血回输治疗的56例外伤性多脏器损伤患者为自体血回输组,对照组为同期单纯输注异体血的同类型患者73例。记录围手术期失血量、异体血输入量、回收血量、输血不良反应及术后感染发生率。应用流式细胞仪测定术前、术后3d及10dT细胞亚群(CD3~+、CD4~+、CD8~+)与NK细胞含量;应用酶标仪测定术前、术后3d与术后10dIgG、IgM和补体C3水平。结果:(1)自体血回输组异体血输入量、输血不良反应和术后感染发生率低于对照组,差异有统计学意义(P<0.05)。(2)对照组术后3d、10d与术前比较,CD3~+、CD4~+、NK细胞、IgG、IgM水平下降(P<0.05),CD8~+水平上升(P<0.05);自体血回输组术后3d、10d与术前比较,C3水平上升(P<0.05);自体血回输组术后3d、10dCD3~+、CD4~+、CD8~+、NK细胞、IgG、IgM、C3水平与对照组比较,差异有统计学意义(P<0.05)。结论:自体血回输对外伤性多脏器损伤患者免疫功能指标的影响较小。
Objective: To investigate the effect of autologous blood transfusion on immune function in traumatic multiple organ injury patients. Methods: Fifty-six traumatic multiple organ injury patients who underwent autologous blood transfusion in the emergency department from 2011-03-2015-09 were autologous blood transfusion group. The control group was the same type of allogeneic blood transfusions during the same period 73 patients. Perioperative blood loss, allogenic blood input, blood volume recovery, adverse transfusion reactions and postoperative infection were recorded. The levels of CD3 +, CD4 +, CD8 + and NK cells were measured by flow cytometry before and 3 days and 10 days after operation. The levels of CD3 + , IgM and complement C3 levels. Results: (1) The incidence of allogeneic blood transfusion, adverse transfusion and postoperative infection in autologous blood transfusion group were lower than those in control group (P <0.05). (2) The levels of CD3 +, CD4 +, NK cells, IgG and IgM in control group decreased (P <0.05) and CD8 + increased (P <0.05) The levels of C3, CD4, CD8 +, NK cells, IgG, IgM, CD3 +, CD3 + and CD3 + C3 levels compared with the control group, the difference was statistically significant (P <0.05). Conclusion: Autologous blood transfusion has little effect on immune function in traumatic multiple organ injury patients.