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用便携式腔内pH记录仪,比较小剂量抗酸剂、西咪替丁和安慰剂对胃酸度的作用。材料和方法:对健康志愿者12名(男7,女5,年龄22～37岁)作随机、双盲、交叉研究。试验期间禁烟、酒,停服可能影响胃内酸度的药物。抗酸剂(氢氧化铝和碳酸镁合剂)疗法:早、中、晚餐后1小时及睡前各服1片(Link 1100mg),咀嚼后用100 ml水送服。西咪替丁疗法:睡前800mg,用100ml水送服。每例作3次试验,每次服药4天,间歇2周以上。于治疗第4天晨插入单晶锑鼻胃导管,顶端置于贲门下10cm处;另一端与腰带上的记录仪相连接。从上午8时起,每4秒测
A portable intracavitary pH logger was used to compare the effect of low-dose antacids, cimetidine, and placebo on gastric acidity. MATERIALS AND METHODS: Twelve (male 7, female 5, age 22-37) healthy volunteers were randomized, double-blind, and crossover studies. No smoking during the test, alcohol, stop taking drugs that may affect gastric acidity. Antacids (aluminum hydroxide and magnesium carbonate mixture) therapy: 1 hour after breakfast, lunch and dinner and before bedtime each 1 (Link 1100mg), after chewing with 100 ml of water delivery. Cimetidine therapy: 800mg before going to bed, with 100ml water delivery service. Each case for 3 tests, each taking 4 days, more than 2 weeks intermittent. In the morning of the fourth day of treatment, a single-crystal antimony nasogastric catheter was inserted, the top of which was placed 10 cm below the cardia and the other end connected to a recorder on the belt. Starting from 8 am, every 4 seconds