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建立了血浆中米托蒽醌的柱切换高效液相色谱测定法，测定和比较了米托蒽醌溶液型注射剂和毫微粒冻干静脉注射剂在家兔体内的血药曲线，并研究比较了二者的药代动力学参数。米托恩醌毫微粒冻干注射剂使米托蒽醌在血中浓度大为降低，血中分布容积增大了近５倍，体内平均驻留时间延长了２倍多。表明米托蒽醌毫微粒有明显的体内长效作用，结合其体内分布试验研究结果，表明其具有明显肝靶向分布作用。
A HPLC method was developed for the determination of mitoxantrone in plasma. HPLC-MS method was developed for the determination of mitoxantrone in plasma and the comparison of the blood drug curve of mitoxantrone solution injection and nano-freeze-dried intravenous injection in rabbits. Pharmacokinetic parameters. Mitoxanil nanoparticles freeze-dried injection of mitoxantrone in the blood concentration was greatly reduced, the blood volume of distribution increased nearly 5-fold, the average residence time in the body more than doubled. Show mitoxantrone nanoparticles have significant long-term effect in vivo, combined with its in vivo distribution test results show that it has obvious liver-targeted distribution.