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核因子κB(NF-κB)是一种与多种基因表达调控有关的核转录因子。基质金属蛋白酶9(MMP-9)对明胶和弹性蛋白有高度的亲和性,在细胞外基质损伤与修复中起重要作用。近年来MMP-9在慢性阻塞性肺疾病(COPD)中的作用受到关注,但其表达调控机制仍未阐明,因此本课题研究了NF-κB抑制剂吡
Nuclear factor κB (NF-κB) is a nuclear transcription factor involved in the regulation of a variety of gene expression. Matrix metalloproteinase 9 (MMP-9) has a high affinity for gelatin and elastin and plays an important role in the injury and repair of extracellular matrix. In recent years, the role of MMP-9 in chronic obstructive pulmonary disease (COPD) has attracted attention, but the mechanism of its expression regulation has not been elucidated. Therefore, we studied the effect of NF-κB inhibitor