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脑梗死是危及生命的一种脑血管病,具有高致残率和高致死率的特点。氧化应激、炎症、钙超载和凋亡在脑梗死的二次损伤中发挥重要作用。近年来,随着医疗技术和理论的发展,人类对脑梗死的二次损伤引起的损害有了更多的认识。褪黑素主要是由是大脑松果体腺合成分泌的一种吲哚类神经内分泌激素,具有抗氧化应激、抗炎症、减轻钙离子超载和抗凋亡作用。近年来,越来越多的证据表明褪黑素可以提高脑梗死后预后,其对脑梗死后的保护作用日益引起越来越多人的关注。本文就褪黑素的生理功能和其对脑梗死后保护作用及其可能机制进行综述。
Cerebral infarction is a life-threatening cerebrovascular disease with high morbidity and mortality. Oxidative stress, inflammation, calcium overload and apoptosis play an important role in the secondary damage of cerebral infarction. In recent years, with the development of medical technology and theory, human beings have gained more understanding of the damage caused by secondary damage of cerebral infarction. Melatonin is mainly produced by the brain pineal gland synthesis and secretion of an indole neuroendocrine hormone, with antioxidant stress, anti-inflammatory, reduce calcium overload and anti-apoptotic effect. In recent years, more and more evidences show that melatonin can improve the prognosis of cerebral infarction, and its protective effect on cerebral infarction is attracting more and more attention day by day. This article reviews the physiological function of melatonin and its protective effect after cerebral infarction and its possible mechanism.