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目的探讨经宫颈宫腔镜子宫肌瘤电切术(TCRM)后瘤体雌激素受体(ER)、孕激素受体(PR)的表达改变和意义。方法 73例入行TCRM治疗的子宫肌瘤患者,在肌瘤组织取出后分别于电切部位(A组)、距电切缘5mm的肌瘤组织(B组)和距电切缘10mm的肌瘤组织(C组)分别取材,采用免疫组化法检测ER和PR的表达。并进行为期至少6个月的随访。结果 73例术后患者中69例治疗有效,另4例B超复查仍有肌瘤存在或复发。该4例患者其中2例为Ⅰ型肌瘤,另2例为Ⅱ型肌瘤。A组肌瘤组织少有ER和PR的表达,B组和C组肌瘤组织有ER和PR的表达,以C组的表达程度最高(F=11.237,P=0.000)(F=14.571,P=0.000)。结论宫腔镜子宫肌瘤电切术可减少雌激素受体和孕激素受体的表达,对减少肌瘤复发有一定作用。
Objective To investigate the changes and significance of estrogen receptor (ER) and progesterone receptor (PR) after transcervical hysteroscopic myomectomy (TCRM). Methods Totally 73 patients with myoma of uterine leiomyoma treated with TCRM were divided into three groups: group A (a), fibroid tissue (group B) 5 mm away from the tumor, and fibroid Tissues (group C) were drawn and the expression of ER and PR were detected by immunohistochemistry. Followed by at least 6 months. Results of 73 cases of postoperative patients, 69 cases of effective treatment, and the other 4 cases of B-ultrasound still fibroid presence or recurrence. Of the 4 patients, 2 were type I fibroids and the other 2 were type II fibroids. The expression of ER and PR in group A and group C were higher than that in group A (P = 0.000) (F = 11.237, P = = 0.000). Conclusion Hysteroscopic resection of uterine fibroids can reduce the expression of estrogen receptor and progesterone receptor, to reduce the recurrence of fibroids have a role.