目的 :探讨急性重症狼疮性肾炎 (LN)的死因及其防治措施。方法 :对急性重症LN死亡患者12例进行回顾性分析。结果 :12例透析治疗的同时 ,给予大剂量甲基强的松龙及环磷酰胺联合冲击治疗。死于感染 6例 (占 5 0 % ) ,心衰 2例 ,电解质紊乱 2例 ,急性呼吸窘迫综合征 1例 ,狼疮性脑炎 1例。结论 :急性重症LN通过积极治疗均非死于急性肾功能衰竭 ,而死因以感染为主 ,与患者全身多脏器损害 ,免疫功能低下及免疫抑制剂使用不当有关 ,此外 ,需提高对狼疮性心肌炎及纠正电解质紊乱的认识 Objective: To investigate the cause of death and prevention of acute severe lupus nephritis (LN). Methods: Acute severe LN death in 12 patients were retrospectively analyzed. Results: 12 cases of dialysis treatment, given high-dose methylprednisolone and cyclophosphamide combined impact treatment. 6 died of infection (50%), 2 cases of heart failure, 2 cases of electrolyte imbalance, 1 case of acute respiratory distress syndrome and 1 case of lupus encephalitis. Conclusion: All the patients with acute severe LN died of acute renal failure by active treatment, but the cause of death was mainly infection, which was related to the systemic multiple organ damage, immunocompromise and improper use of immunosuppressive drugs. In addition, Myocarditis and correct understanding of electrolyte disorders