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1948年,G.W.Harris假设下丘脑有物质控制脑垂体前叶促肾上腺皮质激素(ACTH)的分泌。Guillemin和Saffran等曾分别实验证明下丘脑有一种因子可刺激垂体前叶ACTH的分泌,并命名为促肾上腺皮质激素释放因子(Corticotropin releasing tactor,简称CRF)。经过长达30多年的研究,最近在它的化学结构和生理作用等方面有新的发现。1981年,Vale等人共收集了近50万只羊下丘脑标本,确定羊的CRF是由41个氨基酸组成,分子量4671.00,并已人工合成,1983年,先后找出了羊CRF的DNA排列顺序,人CRF的氨基酸和DNA排列顺序,和鼠CRF的氨基酸排列顺序。人与鼠的CRF
In 1948, G. W. Harris hypothesized that the hypothalamus has substances that control the secretion of adrenocorticotropic hormone (ACTH) in the anterior pituitary gland. Guillemin and Saffran have respectively experimentally demonstrated that there is a factor in the hypothalamus that stimulates the secretion of ACTH in the anterior pituitary and is named as Corticotropin releasing tact (CRF). After more than 30 years of research, there have been new discoveries in its chemical structure and physiological functions recently. In 1981, Vale and others collected a total of nearly 500,000 sheep hypothalamus specimens to determine the sheep CRF is composed of 41 amino acids, a molecular weight of 4671.00, and has been artificially synthesized in 1983, has identified the sheep CRF DNA sequencing , The amino acid and DNA sequence of human CRF, and the amino acid sequence of murine CRF. Human and mouse CRF