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本文简要介绍了多药耐药基因 (MDR- 1)及其产物 P-糖蛋白 (P- GP)正常的结构、分布及其生理功能 ;对 P- GP在肾移植受者中的表达和机制、与急、慢性排异及环孢菌素 (Cs A)的关系加以综述。
In this paper, the normal structure, distribution and physiological functions of multidrug resistance gene (MDR-1) and its product P-glycoprotein (P-GP) were briefly introduced. The expression and mechanism of P- , And the relationship between acute and chronic rejection and cyclosporine (Cs A) were reviewed.