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为探讨氧化型脂蛋白 (a)对巨噬细胞增殖的影响 ,采用细胞计数和MTT掺入观察比较天然型脂蛋白(a)、氧化型脂蛋白 (a)和丙二醛修饰脂蛋白 (a)对培养的鼠腹腔巨噬细胞增殖的影响。结果发现 ,氧化型脂蛋白 (a)在蛋白浓度为 2 .5～ 40mg/L时刺激巨噬细胞增殖 ,蛋白浓度为 40mg/L时巨噬细胞数为对照组的 1.5倍 (P <0 .0 5 )。而天然型脂蛋白 (a)和丙二醛修饰脂蛋白 (a)对巨噬细胞增殖无影响。结果提示 ,氧化型脂蛋白 (a)可能通过促进巨噬细胞增殖加速动脉粥样硬化的发展。
In order to investigate the effect of oxidized lipoprotein (a) on the proliferation of macrophages, the effects of native lipoprotein (a), oxidized lipoprotein (a) and malondialdehyde modified lipoprotein (a ) On the proliferation of murine peritoneal macrophages. The results showed that (1) lipoprotein (a) stimulated the proliferation of macrophages when the protein concentration was 2.5 ~ 40mg / L, and the number of macrophages was 1.5 times that of the control when the protein concentration was 40mg / L (P <0. 0 5). However, native lipoprotein (a) and malondialdehyde modified lipoprotein (a) had no effect on macrophage proliferation. The results suggest that oxidized lipoprotein (a) may accelerate the development of atherosclerosis by promoting macrophage proliferation.