自从世界上部分地区的恶性疟对氯喹产生抗性以来,使原先的标准治疗方案发生很大改变,各种药物的伍用应运而生。抗菌素和抗疟药伍用,因能增加疗效、降低毒性和减轻抗性而备受重视。磺胺类无论与砜类或二氨基嘧啶类伍用,都有高度的协同作用。试管内的实验证明,效果与药物的生物半衰期成正比,浓度相等时,长效磺胺的作用较短效 Since the resistance of Plasmodium falciparum to chloroquine in some parts of the world has changed the original standard treatment regimen, the emergence of various drugs has emerged. Antibiotics and anti-malaria drugs, due to increased efficacy, reduce toxicity and reduce resistance and attention. Sulfonamides are highly synergistic with either sulfones or diaminopyrimidines. Experiments in vitro prove that the effect is proportional to the biological half-life of the drug. When the concentrations are equal, the effect of long-acting sulfonamides is relatively short