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六十年代初期,上海医药工业研究院合成了具有抗日本血吸虫的呋喃丙胺(F_(30066))(Ⅰ)。嗣后,又对其同类物F_(30385)(Ⅱ)的预防及治疗作用进行了实验研究。这一发现不仅填补了治疗日本血吸虫病口服非锑药物的空白,且为抗血吸虫病药物的合成研究提供了重要线索。近年来,国外合成了反式-5-氨基-3-[2-(5-硝基-2-呋喃)乙烯]-1,2,4 (口恶)二唑(SQ_(18506))(Ⅲ),并对其抗血吸虫作用及毒性等进行了不少的实验研究,现将有关资料综述如下。
In the early 1960s, the Shanghai Institute of Pharmaceutical Industry synthesized furanpropylamine (F_ (30066)) (I) against Schistosoma japonicum. Subsequently, we also conducted an experimental study on the preventive and therapeutic effects of its analogue F_ (30385) (Ⅱ). This finding not only fills the gap in the oral non-antimony drug treatment of schistosomiasis japonica, but also provides important clues for the synthesis of anti-schistosomiasis drugs. In recent years, trans-5-amino-3- [2- (5-nitro- 2-furan) ethylene] -1,2,4 (oxadiazole) ), And its anti-schistosome effect and toxicity of a lot of experimental study, the relevant information are summarized below.