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本文报道了对3例小儿乙肝病毒相关性肾炎的肾组织,应用Southcrn印迹法检测出非复制游离型HBV DNA,而在3例非HBV-GN的肾组织中则无HBV DNA。参考以往报道2例HBV-GN的肾组织中有整合型HBV DNA,提示HBV-GN的肾组织中存在HBV DNA不是偶然现象。根据以上研究,作者认为肾组织中HBV DNA如能表达,则可能是HBV抗原的来源之一,被释放后与相应抗体沉着于肾病灶中。
This article reports the detection of non-replicative free HBV DNA by Southcrn blot in 3 kidneys with hepatitis B virus-associated nephritis in children and no HBV DNA in 3 non-HBV-GN kidney tissues. Reference to previously reported two cases of HBV-GN kidney tissue with integrated HBV DNA, suggesting that the presence of HBV DNA in the kidney of HBV-GN is not an accidental phenomenon. According to the above study, the authors believe that if HBV DNA expression in renal tissue, it may be one of the sources of HBV antigens, after being released and the corresponding antibodies in renal lesions.