体外净化骨髓是自身骨髓移植的关键之一。应用免疫磁性微球从骨髓中物理地清除癌细胞是近年来发展起来的崭新方法。磁性微球为聚苯乙烯等高分子材料包裹磁性物质所形成的具有磁响应性的微球,在表面联上单抗后即成免疫磁性微球。微球与癌细胞特异结合后,通过磁场就可有效地清除癌细胞。该法清除癌细胞安全、效果好、操作简便,得到广泛应用。 Purification of bone marrow in vitro is one of the keys to its own bone marrow transplantation. The use of immunomagnetic microspheres to physically remove cancer cells from the bone marrow is a new method that has been developed in recent years. The magnetic microspheres are magnetically responsive microspheres formed of a magnetic material such as polystyrene, and are formed into immunomagnetic microspheres by attaching a monoclonal antibody to the surface. After the microspheres and the cancer cells are specifically combined, the cancer cells can be effectively removed by the magnetic field. The method has been widely used for clearing cancer cells, has good safety, and is easy to operate.