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滤泡辅助性T细胞(Tfh)是近年来发现的调节体液免疫应答的新型CD4+T细胞亚群,Tfh被认为是辅助B细胞产生抗体的最主要的辅助细胞。CD4+CXCR5+是Tfh的标志,Tfh与其他CD4+T亚群存在明显差别,包括转录因子(Bcl-6)、趋化因子受体(CXCR5)的高表达,迁移至淋巴滤泡并辅助B细胞产生抗体等。IL-21是Tfh分泌的辅助性细胞因子,通过与B细胞的IL-21R结合,使之分化为产生抗体的细胞。该类细胞的异常可能与肝脏疾病的发病机制有关。
Follicular helper T cells (Tfh) are a new subset of CD4 + T cells that have been found to regulate the humoral immune response in recent years. Tfh is considered as the most important helper cell to help B cells produce antibodies. CD4 + CXCR5 + is a hallmark of Tfh. Tfh is significantly different from other CD4 + T subpopulations, including the high expression of transcription factors (Bcl-6) and chemokine receptors (CXCR5), migration to lymphoid follicles and the assisting of B cells Produce antibodies and so on. IL-21 is an auxiliary cytokine secreted by Tfh and differentiates into antibody-producing cells by binding to IL-21R of B cells. Abnormalities in this type of cell may be related to the pathogenesis of liver disease.