论文部分内容阅读
目的应用脐血进行产前诊断,探讨高龄孕妇脐血送检染色体核型分析的成功率及异常检出率。方法对产前诊断送检的脐血样本行染色体分析。统计2008年1月至2013年10月1 120份送检脐血染色体核型分析的成功率以及异常检出率,分析高龄因素对染色体分析和异常检出率的影响。结果 2008至2011年产前诊断脐血染色体送检数量呈上升趋势,2011年后逐渐下降,但高龄孕妇所占比例无显著变化。高龄孕妇脐血染色体的成功率与总成功率相当,差异无统计学意义(P>0.05)。异常核型检出率略高于总体检出率,分别为8.33%和5.38%,但差异无统计学意义(P>0.05)。结论脐血细胞遗传产前诊断的减少预示着孕早期筛查和诊断的完善,高龄孕妇的脐血染色体核型异常率略高于总体人群,但高龄因素对脐血染色体细胞遗传检查的成功率和异常检出率无明显影响。
Objective To apply prenatal diagnosis of umbilical cord blood to explore the success rate and abnormal detection rate of karyotype analysis of cord blood in presbyopic pregnant women. Methods Chromosomal analysis of umbilical cord blood samples for prenatal diagnosis. From January 2008 to October 2013, the success rate of karyotype analysis of 11 120 cord blood samples and the detection rate of anomaly were analyzed. The effects of aging on chromosomal analysis and anomaly detection rate were analyzed. Results The number of prenatal diagnosis of umbilical cord chromosome from 2008 to 2011 showed an upward trend, and gradually decreased after 2011, but the proportion of elderly pregnant women did not change significantly. Elderly pregnant women cord blood chromosome success rate and assembly success rate, the difference was not statistically significant (P> 0.05). The detection rate of abnormal karyotype was slightly higher than the overall detection rate of 8.33% and 5.38% respectively, but the difference was not statistically significant (P> 0.05). Conclusion The reduction of prenatal diagnosis of umbilical cord blood cell hematopoiesis indicates the improvement of screening and diagnosis in early pregnancy. The abnormal rate of karyotype of cord blood in older pregnant women is slightly higher than that of the general population. However, Abnormal detection rate no significant effect.