目的：研究丹酚酸Ａ（ＳＡＡ）抗肝损伤、肝纤维化作用．方法：采用ＣＣｌ４诱导大鼠肝损伤及肝纤维化，期间予ＳＡＡ灌胃治疗，另设秋水仙碱（Ｃｏｌ）组、丹参组作对照，６周后进行肝组织病理学和Ⅰ、Ⅲ型胶原免疫组化观察，肝组织羟脯氨酸（Ｈｙｄ）、丙二醛（ＭＤＡ）含量及血清ＡｌａＡＴ、ＡｓｐＡＴ和白蛋白含量测定．结果：ＳＡＡ降低血清ＡｌａＡＴ、ＡｓｐＡＴ水平及肝组织ＭＤＡ、Ｈｙｄ含量，减轻肝纤维化程度，抑制Ⅰ、Ⅲ型胶原在基质中沉积．其抗肝纤维化强度与Ｃｏｌ、丹参一致，对ＭＤＡ作用优于Ｃｏｌ．结论：ＳＡＡ有显著的抗肝损伤、肝纤维化作用，与抗脂质过氧化有关 Objective: To study salvianolic acid A (SA  A) anti-liver injury, liver fibrosis. Methods: CCl4 was used to induce liver injury and hepatic fibrosis in rats. SAA was intragastrically administrated with CCl4. Colchicine group and Salvia miltiorrhiza group were used as controls. After 6 weeks, liver histopathology and Ⅰ, Ⅲ Immunohistochemistry was used to observe the content of hydroxyproline (Hyd), malondialdehyde (MDA) and the content of serum AlaAT, AspAT and albumin in liver tissue. Results: SAA reduced serum AlaAT, AspAT levels and liver MDA and Hyd content, reduce the degree of liver fibrosis, inhibit type Ⅰ, Ⅲ collagen deposition in the matrix. The anti-hepatic fibrosis intensity is consistent with that of Col and salvia miltiorrhiza, and its effect on MDA is better than that of Col. Conclusion: SA  A significant anti-liver injury, liver fibrosis, and anti-lipid peroxidation