目的观察丹酚酸Ａ（ＳＡＡ）抗过氧化肝损伤的作用．方法采用ＣＣｌ４诱导大鼠肝损伤模型，观察ＳＡＡ对肝脏病理、血清Ａｌｂ含量与ＡＬＴ，ＡＳＴ活性，肝组织ＭＤＡ含量的影响．另以ＣＣｌ４熏蒸诱导肝细胞损伤，观察ＳＡＡ对ＡＬＴ，ＡＳＴ，ＧＳＨＰＸ的活性以及对ＭＤＡ，ＧＳＨ含量的变化．结果ＳＡＡ能减轻模型鼠肝脏病理变化，降低ＡＬＴ，ＡＳＴ活性与ＭＤＡ含量；降低损伤肝细胞ＡＬＴ，ＡＳＴ，ＳＯＤ，ＧＳＨＰＸ活性与ＭＤＡ含量，增高ＧＳＨ含量．结论ＳＡＡ具有良好的抗过氧化肝损伤作用． Objective To observe the effect of salvianolic acid A (SAA) on anti-peroxide liver injury. Methods CCl4-induced rat liver injury model was observed SA of liver pathology, serum Alb and ALT, AST activity, liver MDA content. The other CCl4 fumigation induced hepatocellular injury, observed SA  A ALT, AST, GSH  PX activity and MDA, GSH content changes. Results SAA could alleviate the pathological changes of liver, decrease the activity of ALT and AST and the content of MDA, decrease the activity of ALT, AST, SOD, GSHPX and the content of GSH in injured hepatocytes. Conclusions SA  A has a good anti-peroxidative liver injury.