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Ru486(Mifepris,米非司酮)系一种炔诺酮的衍生物,1982年Hermen等首先报道了其抗早孕作用;米索前列醇(Misoprostol)系新的口服前列腺素,1991年开始用于催经止孕,近年来多与Ru486配伍。我院自1992年7月开展药物流产,迄今已收治530例,其中450例系Ru486配伍米索前列醇抗早孕,现将这450例临床资料总结分析如下。(一)对象和方法1.对象:自愿使用药物催经止孕,无心肝肾等重要脏器疾患,无青光眼、哮喘及高血压病史,近期无激素类药物使用史,服药前妇检无异常发现,未放置宫内节育器,血常规、肝功能属正常范围,尿βHCG25mIU/ml以上。年龄19～39岁。停经天数在32～52天,其中42天及以下346例,42天以上104例(其中49天以上5例)。450例均经B超
Ru486 (Mifepris, mifepristone), a derivative of norethindrone, was first reported by Hermen et al in 1982 for its anti-early pregnancy effect. Misoprostol, a new oral prostaglandin, was used in 1991 After cessation of pregnancy, and more in recent years with Ru486 compatibility. Our hospital since July 1992 to carry out medical abortion, so far has received 530 cases, of which 450 cases of Ru486 compatibility with misoprostol anti-early pregnancy, now 450 cases of clinical data summarized as follows. (I) Subjects and Methods 1. Subjects: Voluntary use of drugs to promote pregnancy, heart and liver and other important organs without heart disease, no history of glaucoma, asthma and hypertension, the recent history of hormone-free medication, medication before the test no abnormal Found, did not place IUD, blood, liver function is normal, urine βHCG25mIU / ml or more. Age 19 ~ 39 years old. Menopause days in 32 to 52 days, of which 42 days and below 346 cases, more than 42 days in 104 cases (of which 49 days over 5 cases). 450 cases were B ultrasound