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目的研究系统性红斑狼疮患者行自体外周血CD34+造血干细胞移植术后血清中自身抗体的变化规律。方法12例患者接受自体造血干细胞移植,应用ELISA法检测移植前后血清中自身抗体的含量,并进行定量分析。结果移植6个月后患者血清中自身抗体的含量恢复正常。结论自体外周血CD34+造血干细胞移植能减少患者血清中的自身抗体,有效治疗系统性红斑狼疮。
Objective To study the changes of serum autoantibodies in patients with systemic lupus erythematosus after autologous peripheral blood CD34 + hematopoietic stem cell transplantation. Methods Twelve patients underwent autologous hematopoietic stem cell transplantation. The levels of autoantibodies in serum before and after transplantation were measured by ELISA and quantified. Results Six months after transplantation, serum autoantibodies returned to normal. Conclusion Autologous peripheral blood CD34 + hematopoietic stem cell transplantation can reduce the serum autoantibodies in patients with systemic lupus erythematosus.