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黑素瘤抗原-1(Melanoma antigen-1,MAGE-1)是Vander Bruggen等[1]于1991年在研究恶性黑素瘤时发现的人类第一个肿瘤特异性抗原,现已形成拥有24个结构上相似的MAGE基因成员的家族[2]。MAGE蛋白及其细胞毒性T淋巴细胞(Cytolytic T lymphocyte,CTL)表位不仅能在体外有效诱
Melanoma antigen-1 (MAGE-1) is the first human tumor-specific antigen discovered by Vander Bruggen et al [1] in 1991 in the study of malignant melanoma. Now there are 24 Structurally similar families of MAGE genes [2]. MAGE protein and its cytotoxic T lymphocyte (CTL) epitopes can not only effectively induce in vitro