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α-干扰素(IFN-α)治疗慢性乙型肝炎(CHB)是很有希望的治疗方法,但有许多副作用,最常见的是引起流感样症状。近来已有IFN治疗后产生自身抗体的报道,这些抗体不是与慢性活动性肝炎(CAH)有关的抗体,但IFN治疗CHB也许能诱导加重肝病的自身免疫反应。作者分析了接受IFN治疗的慢性乙型肝炎病人的自身抗体,着重分析了那些典型地出现在慢性肝脏疾病,如自身免疫型CAH的各种亚型和原发性胆汁性肝硬变的自身抗体。研究对象为经活检证实的HBsAg阳性CAH病人31例(男27、女4)。他们的HBsAg、
Treatment of chronic hepatitis B (CHB) with interferon-alpha (IFN-α) is a promising treatment but has many side effects, the most common being flu-like symptoms. Recently, there have been reports of autoantibodies produced after IFN treatment. These antibodies are not antibodies related to chronic active hepatitis (CAH), but IFN treatment of CHB may induce an autoimmune response that aggravates liver disease. The authors analyzed autoantibodies in patients with chronic hepatitis B treated with IFN and focused on those autoantibodies that typically occur in various forms of chronic liver disease such as autoimmune CAH and primary biliary cirrhosis . The subjects were 31 HBsAg-positive CAH patients confirmed by biopsy (male 27, female 4). Their HBsAg,