6氨基己酸(EACA)曾以较小剂量作为抗纤溶剂,目前转用较大剂量以治疗遗传性神经性水肿。作者报告一例24岁女病人,应用大剂量EACA而引起横纹肌松解和出现肌球蛋白尿。此病人因注射DNA过敏而反复出现疼痛性皮下出血已16年,经常用EACA治疗。最近一次出血用每6小时6克EACA,4周后逐渐感觉肢体近端肌肉无力与肌痛,2天后小便呈暗褐色。肢体无力进行性加重,入病当天已不能上楼。病人最后1剂EACA距急诊时间约10小时。病人无其他特殊病史。入病时尿呈红褐色,硫酸铵沉淀 6 aminocaproic acid (EACA) had smaller doses as anti-fibrinolysis, the current switch to larger doses to treat hereditary edema. The authors report a 24-year-old female patient who developed striated muscle relaxations and myosinuria with high-dose EACA. This patient has recurrent painful subcutaneous hemorrhage due to DNA allergy injection for 16 years and is often treated with EACA. The most recent bleeding with 6 grams of EACA every 6 hours, 4 weeks after gradual sensation of muscle weakness and muscle pain in the proximal limbs, dark urine after 2 days. Physical weakness progressive increase, the day has been unable to go upstairs. The last dose of patient EACA was about 10 hours away from the emergency department. The patient has no other special medical history. When the disease was urine brown, ammonium sulfate precipitation