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[目的]探讨Maspin蛋白在胃癌组织中的表达以及与术后化疗后生存时间的关系。[方法]选取临床病理资料完整并随访3年以上的胃癌术后组织标本,将每例术后胃癌组织应用Maspin单克隆抗体进行SP免疫组化染色,定期随访患者。结合临床及病理形态学资料采用生存曲线和COX模型分析术后接受化疗患者胃癌组织Maspin表达与化疗后生存时间的关系。[结果]Maspin蛋白在胃癌组织中的阳性表达率为58.1%。Maspin表达阳性者化疗后生存时间明显延长。[结论]Maspin蛋白表达情况与胃癌术后化疗后生存时间有关。
[Objective] To investigate the expression of Maspin protein in gastric cancer and the relationship with survival time after chemotherapy. [Method] The tissue specimens of gastric cancer with clinicopathological data intact and followed up for more than 3 years were selected. Maspin monoclonal antibody was used for SP immunohistochemical staining in each of the cases. The patients were followed up regularly. Combined with clinical and histopathological data, survival curves and COX model were used to analyze the relationship between Maspin expression and survival time after chemotherapy in gastric cancer patients undergoing chemotherapy. [Results] Maspin protein expression in gastric cancer was 58.1%. Maspin expression was significantly longer survival time after chemotherapy. [Conclusion] The expression of Maspin protein is related to the survival time of postoperative chemotherapy of gastric cancer.