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目的:研究溶血性链球菌感染引起的风湿病患者抗DNA酶B和ASO的血清学变化及意义。方法:收集30例急性风湿热、30例活动期风湿性心脏病、30例风湿性关节炎患者血清,免疫散射比浊法检测其抗DNA酶B和ASO水平。结果:三组患者的ASO阳性率分别为80%、57.3%、53.3%,抗DNA酶B检测阳性率分别为70%、85.7%、60%。除活动期风湿性心脏病组外,其余两组患者的ASO阳性率与抗DNA酶B检测阳性率间的差异无统计学意义(P>0.05)。三组患者的抗DNA酶B和ASO联合检测阳性率分别为90%、92.8、80%,均高于单一检测(P<0.05)。结论:ASO和抗DNA酶B抗体联合检测可提高风湿热诊断阳性率,对风湿热的诊断具有重要的临床意义。
Objective: To study the serological changes of DNase B and ASO in patients with rheumatic diseases caused by hemolytic streptococcus infection. Methods: Thirty patients with acute rheumatic fever, 30 active rheumatic heart disease and 30 rheumatoid arthritis were collected. The levels of anti DNase B and ASO were detected by immunostaining turbidimetry. Results: The positive rates of ASO in the three groups were 80%, 57.3% and 53.3% respectively, and the positive rates of anti DNase B were 70%, 85.7% and 60% respectively. Except active rheumatic heart disease group, there was no significant difference between ASO positive rate and anti DNase B positive rate in the other two groups (P> 0.05). The positive rates of combined detection of DNase B and ASO in the three groups were 90%, 92.8% and 80%, respectively, which were higher than the single detection (P <0.05). Conclusion: The combined detection of ASO and anti-DNase B antibody can increase the positive rate of diagnosis of rheumatic fever, and has important clinical significance for the diagnosis of rheumatic fever.