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目的观察归脾汤加减治疗感染相关性中性粒细胞减少症的临床疗效。方法选取2013年9月至2014年9月我院收治的符合诊断标准的感染相关性中性粒细胞减少症患儿,随机分为治疗组和对照组,对照组在常规治疗的基础上口服利可君片,治疗组在对照组治疗的基础上加用归脾汤加减口服治疗。观察其临床症状改善、中性粒细胞值及T细胞亚群CD_4~+,CD_8~+值的变化。结果治疗组总有效率(96.67%)显著高于对照组(63.33%),差异有统计意义(P<0.05);2组患儿治疗后第4天、第7天,治疗组患儿中性粒细胞值均升高,且显著高于对照组,差异有高度统计意义(P<0.01);治疗后,治疗组CD_4~+,CD_4~+/CD_8~+均升高,CD_8~+下降,与对照组比较,差异有高度统计意义(P<0.01)。结论归脾汤加减治疗感染相关性中性粒细胞减少症,能改善患儿的临床症状、明显提高中性粒细胞值及调节免疫功能。
Objective To observe the curative effect of Guipi Decoction on infection-associated neutropenia. Methods Children with infection-associated neutropenia who met the diagnostic criteria admitted to our hospital from September 2013 to September 2014 were randomly divided into treatment group and control group. The control group received oral administration on the basis of routine treatment Kejun tablets, the treatment group in the control group based on the treatment with Guipi Decoction plus oral treatment. To observe the clinical symptoms, neutrophil and T cell subsets CD_4 ~ +, CD_8 ~ + value changes. Results The total effective rate (96.67%) in the treatment group was significantly higher than that in the control group (63.33%), the difference was statistically significant (P <0.05). On the 4th and 7th day after treatment, (P <0.01). After treatment, CD_4 ~ +, CD_4 ~ + / CD_8 ~ + increased and CD_8 ~ + decreased in the treatment group, and the difference was statistically significant Compared with the control group, the difference was highly statistically significant (P <0.01). Conclusion Guipi Decoction treatment of infection-related neutropenia, can improve the clinical symptoms of children, significantly increased neutrophil value and regulate immune function.