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在已经加碘得到控制的碘缺乏性疾病病区,观察了地方性克汀病垂体--性腺系统对促黄体激素释放因子(LHRH)试验的反应。结果:男性克汀病病人组血清黄体生成激素(LH)和卵泡刺激素(FSH)基础值显著高于对照组,但其血清睾酮(T)值则显著低于对照组。静脉注射 LHRH100μg15分钟后,克汀病病人组血清 FSH 反应高于正常人组,LH 反应与正常对照组相似。两组血清 T 值于试验后无显著变化。静脉注射接着静脉滴注 LHRH,克汀病病人组 FSH 反应高于正常人,其 LH 最大增值和反应倍数均低于对照组,正常人组 LH、FSH 呈双相反应,克汀病病人组则无此反应。血清 T,正常人组试验后2-3小时显著升高,克汀病病人组无则显著变化。结果表明克汀病病人不仅有原发性 Leydig 和 Sertoli 细胞功能低下,而且还有垂体促性腺激素储备和再合成功能的减低。
The response to the luteinizing hormone releasing factor (LHRH) test of the local cretinosis-gonadal system was observed in areas of iodine deficiency disorders where iodine has been controlled. Results: The basal values of serum LH and FSH in patients with cretinism were significantly higher than those in the control group, but the serum testosterone (T) values were significantly lower than those in the control group. After intravenous injection of LHRH100μg for 15 minutes, the serum FSH response of patients with cretinism was higher than that of normal subjects, and the LH response was similar to that of normal controls. The serum T values of the two groups showed no significant changes after the test. Intravenous injection followed by intravenous infusion of LHRH, cretinism in patients with FSH response was higher than normal, the maximum value of LH and response fold were lower than the control group, normal group LH, FSH showed a biphasic response cretinism patient group No such reaction. Serum T, normal group significantly increased 2-3 hours after the test, cretinism patient group no significant change. The results showed that patients with cretinism not only dysfunctional primary Leydig and Sertoli cells, but also reduced pituitary gonadotropin reserve and re-synthesis.