TNF是新一代生物反应调节剂,已日益受到重视,并在临床应用中展示出良好的苗头,TNF作用的重要机制是自由基的产生,但其疗效受较多因素的影响.本文以TNF和自由基为线索探讨了两者对大肠癌细胞的细胞毒作用关系及对脂质过氧化物、膜脂流动性的影响.结果表明:(1)TNF和tbooH在体外均可抑制大肠癌细胞的生长,而且tbooH能明显加强TNF的细胞毒作用.(2)INF、tbooH和TNF+tbooH在 TNF is a new generation of biological response modifiers, has been increasingly valued and has shown good signs in clinical applications. The important mechanism of TNF action is the production of free radicals, but its efficacy is affected by many factors. This article uses TNF and Free radicals are the clues to explore the cytotoxic effects of the two on colorectal cancer cells and their effects on lipid peroxides and membrane fluidity. The results show that: (1) Both TNF and tbooH can inhibit the growth of colorectal cancer cells in vitro. Growth, and tbooH can significantly enhance the cytotoxic effects of TNF. (2) INF, tbooH, and TNF+tbooH are