Dubin-Johnson综合征是一种非溶血性、非梗阻性,以结合型胆红素增高为主的间歇性黄疸,在肝细胞中有特殊的色素沉着,曾称为特发性黄疸.目前称结合型胆红素增高Ⅰ型.此病临床少见,多误诊为慢性活动性肝炎,我们几年来收治三例,现结合临床对该病报告如下: Dubin-Johnson syndrome is a non-hemolytic, non-obstructive, combined with elevated bilirubin-based intermittent jaundice, in liver cells have a special pigmentation, was called idiopathic jaundice. Combined bilirubin increased type Ⅰ. The disease is clinically rare, often misdiagnosed as chronic active hepatitis, we admitted to the past few years, are now combined with clinical reports of the disease are as follows: