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本文采用放射免疫分析法,对64例高危新生儿和49例正常新生儿脐血β_2-mG的检测分析。结果:高危新生儿β_2-mG±SD为3.92±0.97μg/ml,显著高于正常新生儿(P<0.01),男女性别无差异(P>0.05)。64例高危新生儿中10例其母为妊高征、21例过期产儿、33例早产儿脐血β_2-mG值分别与49例正常新生儿脐血β_2-mG值进行了比较,其结分别为t=2.62,P<0.05;t=2.63,P<0.05;t=4.35,P<0.01。高危新生儿组体重<2500克23例,>2500克为41例,β_2-mG的(?)±SD分别为4.36±0.89和3.67±0.93,两者相比有极为显著差异(P<0.01)。正常新生儿体重>2500克组49例,与高危新生儿组>2500克41例相比,有极为显著差异(P<0.01)。新生儿体重越低,β_2-mG含量越高;脐血β_2-mG含量越高,新生儿死亡率亦高。实验证实:β_2-mG从肾小球滤过,肾功能影响β_2-mG的含量。胎盘功能减退,胎盘血灌注不足直接影响新生儿肾小球滤过率(GFR),使血β_2-mG排泄减少,从而导致高危新生儿β_2-mG升高。所以,脐血β_2-mG检测,对了解胎儿肾脏的发育和肾功能受损的程度,以及肾功能恢复和预后的监测,有一定的临床价值。
In this paper, radioimmunoassay, 64 cases of high-risk neonates and 49 normal newborn cord blood β_2-mG detection analysis. Results: The high-risk neonatal β_2-mG ± SD was 3.92 ± 0.97μg / ml, which was significantly higher than that of the normal newborns (P <0.01). There was no difference between male and female (P> 0.05). Sixty-four high-risk neonates were enrolled in this study. The mothers were PIH, 21 cases of expired children and 33 cases of preterm infants with β_2-mG values of umbilical cord blood, respectively, compared with 49 normal newborns with β_2-mG values. T = 2.62, P <0.05; t = 2.63, P <0.05; t = 4.35, P <0.01. The high-risk neonates had weight <2500 g in 23 cases,> 2500 g in 41 cases and β_2-mG ± SD in 4.36 ± 0.89 and 3.67 ± 0.93, respectively (P <0.01) . 49 cases of normal neonates weighing> 2500g had extremely significant difference compared with 41 cases of high risk neonates> 2500g (P <0.01). The lower the newborn’s body weight is, the higher the content of β_2-mG; the higher the umbilical β_2-mG content is, the higher the neonatal mortality rate is. Experiments confirmed: β_2-mG from the glomerular filtration, renal function affect β_2-mG content. Placental dysfunction, lack of placental blood perfusion directly affects neonatal glomerular filtration rate (GFR), decreased blood β2-mG excretion, resulting in high-risk neonatal β_2-mG increased. Therefore, umbilical cord blood β_2-mG detection, to understand the development of fetal kidneys and renal damage, as well as renal function recovery and prognosis of the monitoring, have some clinical value.