人组织型纤维蛋白溶酶原激活剂(t-PA)与尿激酶、链激酶都能激活纤溶酶原,溶解血栓,但t-PA却能选择性地激活血凝块中的纤溶酶原,不激活血流中的纤溶酶原。因此t-PA溶解血栓的疗效显著,作用专一,且无全身性内出血倾向等副反应。但是,人和动物组织及体液中t-PA含量极微,难以制成药用;t-PA的分子量为72 000,很难用有机合成法生产;Bowes人黑色素瘤培养细胞(Bowes细胞)株能 Human tissue-type plasminogen activator (t-PA) and urokinase, streptokinase can activate plasminogen, thrombolytic, but t-PA was able to selectively activate plasminogen in the clot The original, does not activate plasminogen in the bloodstream. Therefore, t-PA thrombolytic significant effect, role-specific, and no systemic side effects such as bleeding tendency. However, the t-PA content in human and animal tissues and body fluids is extremely low and it is difficult to make it into a medicinal product. The molecular weight of t-PA is 72,000 and it is difficult to produce it by the organic synthesis method. Bowes human Bowes cell strain can