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作者观察了电离辐射后小肠粘膜及血浆中二肢氧化酶(DAO)活性的变化.动物受6Gyγ射线照射后1天,小肠粘膜DAO活性即开始下降,3天降至最低,5天开始回升,15~25天酶的活性高于正常值,血浆中DAO活性的变化与小肠中酶活性的变化趋势基本相似.不同剂量照射后第3天,随着剂量的增大,小肠和血浆中DAO活性呈线性下降.通过肠上皮细胞量与DAO活性两者关系的研究表明:照后上皮细胞数的变比与DAO活性的改变基本一致.因此,认为血浆中DAO活性的变化可作为反映小肠粘膜放射损伤与修复的一个生物学指标.
The authors observed changes in intestinal mucosa and plasma dioxygenase (DAO) activity after ionizing radiation. One day after exposure to 6 Gy γ-rays, the activity of DAO began to decline in the intestinal mucosa, decreased to the lowest level in 3 days, started to rise in 5 days, and activity of enzyme in 15-25 days was higher than normal. The change of DAO activity in plasma and the activity of intestinal enzymes The trend of activity is basically similar. On the 3rd day after different dose irradiation, the DAO activity in the small intestine and plasma decreased linearly with the dose increasing. The relationship between the amount of intestinal epithelial cells and the activity of DAO showed that the ratio of epithelial cells after irradiation changed basically in line with the change of DAO activity. Therefore, it is thought that the change of plasma DAO activity can be used as a biological indicator to reflect the damage and repair of small intestinal mucosa.