论文部分内容阅读
本文以离体测定和整体实验相结合,测定了新鲜及温育后的红细胞裂解产物和血小板对离体基底动脉的收缩作用,并测定了实验性家兔蛛网膜下腔出血(Subarachnoid hemorrhage SAH)后前列腺素及血小板聚集性的变化,据此探讨了红细胞,血小板和所测前列腺素在SAH后晚期脑血管痉挛发病中可能的作用。实验结果表明:在体外,红细胞裂解产物和血小板都有明显的缩血管作用,温育5—10天,前者的缩血管作用显著下降,但并不消失;而后者的作用仍然保持,甚至所减增强。加热100℃10分钟,红细胞裂解产物失去缩血管作用,而血小板的缩血管作用并不减
In this study, in vitro and in vivo experiments were combined to determine the contractile effect of fresh and incubated erythrocyte lysate and platelets on isolated basilar artery. The effects of subarachnoid hemorrhage (SAH) Prostaglandin and platelet aggregation changes, thus exploring the possible role of erythrocytes, platelets and prostaglandins measured in the pathogenesis of advanced cerebral vasospasm after SAH. The experimental results show that: In vitro, erythrocyte lysate and platelets have obvious vasoconstrictive effect, incubation of 5-10 days, the former vasoconstrictor effect decreased significantly, but does not disappear; while the role of the latter still maintained, or even reduced Enhanced. Heated at 100 ℃ for 10 minutes, the lysate of erythrocytes loses vasoconstrictive effect, while the vasoconstrictor effect of platelets does not decrease