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目的:经观察评价亚叶酸(FA)/5-氟尿嘧啶(5-FU)对减少手术切除Dukes B_2与C期结肠癌患者复发率的疗效。 材料和方法:由3个手术组按相同的预定手术技术进行结肠癌切除术。术后三周内开始辅助化疗。第1～5天静脉注射FA 200 mg/m~2及5-FU 200 mg/m~2,每4周为一周期,共12周期。除观察复发率以外,还观察了无病间期和生存率。平均随访4.5年(2.5～7.5年)。239例患者中Dukes B_2期121例,Dukes C期118例,随机分为FA/5-FU组及单纯观察组。 随访:第一年每3个月作病史、体检、血液
OBJECTIVE: To evaluate the efficacy of folinic acid (FA)/5-fluorouracil (5-FU) in reducing the recurrence rate of patients undergoing surgical resection of Dukes B2 and C stage colon cancer. Materials and Methods: Colon cancer resection was performed on the same scheduled surgical technique in 3 surgical groups. Adjuvant chemotherapy was started within three weeks after surgery. On the first to fifth days, FA 200 mg/m 2 and 5-FU 200 mg/m 2 were injected intravenously, every 4 weeks for one cycle, for a total of 12 cycles. In addition to observing the recurrence rate, disease-free intervals and survival rates were also observed. The average follow-up was 4.5 years (2.5 to 7.5 years). Of the 239 patients, 121 were Dukes B 2 and 118 Dukes C were randomly divided into the FA/5-FU group and the observation group. Follow-up: history, physical examination, blood every 3 months in the first year