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为了解暴露于抗肿瘤药物环境或从事放射工作对染色体的影响,评价职业防护的效果,作者对42名在工作中接触顺铂、5-氟尿嘧啶、环磷酰胺、甲氨喋呤和阿霉素等抗癌药物的肿瘤科护士和同一家医院中的42名放射科技术人员做了调查,另选42名无抗肿瘤药物和电离辐射职业暴露的护士作为对照组。调查受试者的吸烟、服药、疾病、2年内的预防接种,职业暴露史以及职业防护设施等情况,并根据年龄进行配对研究。采集受试者血液标本作淋巴细胞培养,计数每人200个细胞中的染色单体和染色体畸变数量,并作统计学处理。结果,肿瘤科护士防护设施较差,而且多数人员没有经过有关的药物知识培训,对抗肿瘤药物的危害性认识不够。放射科技术人员防
In order to understand the effect of occupational protection on exposure to antineoplastic drugs or the radiological work on chromosomes, the authors evaluated 42 workers exposed to cisplatin, 5-fluorouracil, cyclophosphamide, methotrexate and doxorubicin Oncology nurses such as anti-cancer drugs and 42 radiology technicians in the same hospital conducted a survey. Another 42 nurses without occupational exposure to anticancer drugs and ionizing radiation were selected as the control group. Subjects were investigated for smoking, medication, illness, vaccination within 2 years, history of occupational exposure and occupational protection facilities. Matching studies were conducted according to age. Subject blood samples were collected for lymphocyte culture. The number of chromosomal and chromosomal aberrations in 200 cells per human was counted and statistically analyzed. As a result, oncology nurses have poorer protective facilities and most of them do not have enough knowledge about the dangers of oncology drugs after they have not been trained in relevant drug knowledge. Radiological technicians prevent