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摘要目的评价CT能谱成像在评估血管内皮生长因子(VEGF)受体抑制剂AG-013763治疗兔VX2肝癌疗效中的价值。方法使用能谱成像模式对23只VX2肝癌的荷瘤兔进行动脉期(AP)及门静脉期(PP)CT扫描。治疗组(17例)的肿瘤碘浓度(IC)经主动脉校准后的碘浓度(n IC)在不同时间点(基线,治疗后2、4、7、10 d)进行组内比较,同时与对照组(6例)进行组间比较。分析肿瘤大小、坏死部分(NF)、微血管密度(MVD)和n IC之间的关系。结果治疗组n IC相对于基
Abstract Objective To evaluate the value of CT spectral imaging in the evaluation of the therapeutic effect of vascular endothelial growth factor (VEGF) receptor AG-013763 on VX2 liver cancer in rabbits. Methods Twenty-three VX2 hepatocellular carcinoma-bearing rabbits were subjected to arterial phase (AP) and portal vein (PP) CT scans using spectral imaging. Tumor iodine concentration (IC) of the treated group (n = 17) was compared intra-artinally at different time points (baseline, 2, 4, 7 and 10 days after treatment) Control group (6 cases) were compared between groups. The relationship between tumor size, necrosis (NF), microvessel density (MVD) and n IC was analyzed. Results Treatment group n IC vs. base