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找不到原发灶的癌肿病例在临床上并不少见,许多人为此不惜投以大量精力和物力搜寻癌肿的原发灶。尽管如此,其检出率也不到10%,甚至尸检也很难发现。1980年Steckel等报告255例找不到原发灶的癌肿患者中,231例死亡,其中34例做了尸检,仅10例明确原发灶。在恶性肿瘤中,约10%被首先发现的是转移灶,有时生前始终找不到原发灶。为了避免盲目检查,减少患者痛苦,近年来有人倾向将不明原发灶的癌肿作为一种临床综合征—CUP综合征(Careinoma unknown primary)。
It is not uncommon to find cases of cancer of the primary lesion in clinical practice. Many people do not hesitate to invest a lot of energy and resources to search for the primary lesion of cancer. In spite of this, the detection rate is less than 10%, and even autopsy is difficult to find. In 1980, Steckel et al. reported that 231 of the 255 patients with primary lesions that failed to find a primary lesion died, of whom 34 had an autopsy and only 10 had a primary lesion. Of the malignant tumors, about 10% are first found to be metastases, and sometimes they cannot always find the primary lesion. In order to avoid blind examinations and reduce the suffering of patients, in recent years, there is a tendency to use the cancer of unknown primary lesion as a clinical syndrome, Careinoma unknown primary.