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目的探讨空腹血糖受损(IFG)患者臂踝动脉脉搏波传导速度(baPWV)的变化。方法随机分层抽取唐山开滦(集团)有限责任公司在职及离退休职工中年龄≥40岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者共5440例为调查对象,排除资料不完整者,最终纳入统计分析的为5192人。进行血液生化及baPWV检查,根据2003年美国糖尿病学会IFG诊断标准分为理想血糖组、IFG组、糖尿病组,用多因素Logistic回归分析IFG与baPWV的关系。结果与理想血糖组比较,IFG组baPWV较高[左侧:(1580±379)比(1516±380)cm/s;右侧:(1568±344)比(1507±368)cm/s;均P<0.05]。校正了年龄、性别、吸烟、饮酒、收缩压、体质量指数、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、C反应蛋白后,IFG仍是baPWV增加的独立危险因素(OR=1.314,95%CI1.104～1.563)。结论 IFG是baPWV增加的独立危险因素。
Objective To investigate the changes of brachial-ankle pulse wave velocity (baPWV) in patients with impaired fasting glucose (IFG). Methods A total of 5440 cases of ischemic stroke, transient ischemic attack and myocardial infarction in Tangshan Kailuan (Group) Co., Ltd were enrolled in the study. Excluding incomplete data, the final inclusion of 5192 people in the statistical analysis. According to the American Diabetes Association IFG diagnostic criteria in 2003, the patients were divided into ideal blood glucose group, IFG group and diabetic group. The relationship between IFG and baPWV was analyzed by multivariate Logistic regression. Results Compared with the ideal blood glucose group, the baPWV in the IFG group was higher (left: (1580 ± 379) vs (1516 ± 380) cm / s and right: (1568 ± 344) vs (1507 ± 368) cm / P <0.05]. IFG was still an independent risk factor for increased baPWV after adjusting for age, sex, smoking, drinking, systolic blood pressure, body mass index, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and C-reactive protein (OR = 1.314, 95% CI 1.104 ~ 1.563). Conclusion IFG is an independent risk factor for increased baPWV.