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目的观察孟鲁司特钠(白三烯受体拮抗剂,顺尔宁,默沙东)早期干预治疗肺炎支原体感染对预防哮喘的作用。方法选择2008年2月至2009年4月在本院儿科住院的150例肺炎支原体感染患儿(符合入选标准),随机分为观察组和对照组,两组均采用常规抗支原体的基础治疗,观察组同时予以孟鲁司特钠治疗四周后观察哮喘的发病情况。结果肺炎支原体感染后常规应用大环内酯类抗生素抗支原体及对症治疗,辅以孟鲁司特钠进行治疗后,哮喘的发病率明显低于对照组。结论选择孟鲁司特钠可阻断肺炎支原体感染后作为变应原刺激呼吸道的炎症反应,降低气道的高反应性,减少粘液分泌,缓解支气管痉挛,降低哮喘的发病率。
Objective To observe the effect of early intervention with montelukast sodium (leukotriene receptor antagonist, sirolimus, meclizine) on the prevention of asthma by Mycoplasma pneumoniae infection. Methods A total of 150 children with mycoplasma pneumoniae infection admitted to our pediatric department from February 2008 to April 2009 were enrolled in this study. The patients were randomly divided into observation group and control group. Both groups were treated with routine anti-mycoplasma therapy, The observation group was treated with montelukast sodium four weeks later to observe the incidence of asthma. Results Mycoplasma pneumoniae infection after conventional use of macrolide antibiotics against mycoplasma and symptomatic treatment, combined with montelukast sodium treatment, the incidence of asthma was significantly lower than the control group. Conclusion Montelukast sodium can block Mycoplasma pneumoniae infection as an allergen to stimulate the respiratory tract inflammatory response, reduce airway hyperresponsiveness, reduce mucus secretion, relieve bronchial spasm, and reduce the incidence of asthma.