论文部分内容阅读
对189例老年人胃炎的胃粘膜活检标本,采用S-P免疫组化法,观察P53、P21、C-erb B-2基因蛋白表达情况。结果发现,P53在慢性浅表性胃炎(CSG)和慢性萎缩性胃炎(CAG)的单纯型、增生型、肠化型中不表达,而CAG的异型性型中阳性表达11.1％;P21在CSG和CAG的单纯型、增生型、肠化型和异型性型中阳性表达分别为2.2％,4.3％,5.3％,15.2％和48.1％;C-erb B-2在CSG和CAG的单纯型、增生型、肠化型和异型性型中阳性表达分别为4.4％,6.5％,10.5％,21.2％和59.2％。P53与P21、C-erb B-2基因之间的阳性表达有显著性差异(P<0.01);CSG和CAG的单纯型、增生型、肠化型与CAG的异型性型之间比较有显著性差异(P<0.01);3种基因有相关性,均参与了胃癌的发生发展。
Gastric mucosal biopsies from 189 elderly patients with gastritis were examined for the expression of P53, P21 and C-erb B-2 by S-P immunohistochemistry. The results showed that P53 was not expressed in simple, hyperplastic and intestinal metaplasia of chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG), but positive in CAG atypia (11.1%). P21 was found in CSG The positive expression rates of C-erbB-2 and CAG in simple, hyperplastic, intestinal metaplasia and atypia were 2.2%, 4.3%, 5.3%, 15.2% and 48.1% The positive expression in proliferative, intestinal metaplasia and atypia was 4.4%, 6.5%, 10.5%, 21.2% and 59.2% respectively. P53 and P21, C-erb B-2 gene expression was significantly different (P <0.01); CSG and CAG simplex, hyperplastic, intestinal metaplasia and CAG atypia between the more significant (P <0.01). The three genes were correlated and all involved in the occurrence and development of gastric cancer.