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目的探讨抑癌基因P16和细胞周期蛋白D1(CyclinD1)在胃癌组织中的表达及其临床意义。方法应用组织芯片和免疫组织化学方法检测85例老年人胃癌标本中P16基因及CyclinD1蛋白的表达。结果 P16和CyclinD1蛋白在85例老年人胃癌组织中的表达率分别为52.9%(45/85)和75.3%(64/85)。结论 P16与CyclinD1的相互作用可能参与了老年人胃癌的发生,联合检测P16与Cy-clinD1蛋白有助于判断老年人胃癌的恶性程度和生物学行为。
Objective To investigate the expression of tumor suppressor gene P16 and cyclin D1 in gastric carcinoma and its clinical significance. Methods Tissue microarrays and immunohistochemistry were used to detect the expression of P16 gene and CyclinD1 protein in 85 elderly patients with gastric cancer. Results The positive rates of P16 and CyclinD1 in gastric cancer tissues of 85 elderly patients were 52.9% (45/85) and 75.3% (64/85), respectively. Conclusions The interaction between P16 and CyclinD1 may be involved in the pathogenesis of gastric cancer in the elderly. Combined detection of P16 and Cy-clinD1 proteins may be useful in judging the malignancy and biological behavior of gastric cancer in the elderly.