论文部分内容阅读
利用K2CO3作催化剂催化水杨醛类化合物与丙二酸二乙酯或乙酰乙酸乙酯(或甲酯),通过Knoevenagel缩合反应快速简便地合成了10种3-取代香豆素衍生物。探讨了三因素对合成香豆素-3-甲酸乙酯产率的影响,结果表明,水杨醛为20 mmol,水杨醛与丙二酸二酯摩尔比为1∶1.2,K2CO3用量为0.1 mmol,反应15~18 min,产率可达88.1%;当用乙酰乙酸乙酯(或甲酯)代替丙二酸二乙酯时,得到3-乙酰基香豆素,产率达84.7%(或82.9%);当用固态的取代水杨醛代替水杨醛分别与丙二酸二乙酯和乙酰乙酸乙酯(或甲酯)在摩尔比为1∶2.0条件下反应时,得到8种3-取代香豆素衍生物,产率达62.5%~89.0%(或58.1%~83.0%)。
K3CO3 was used as catalyst to catalyze the synthesis of 10 3-substituted coumarin derivatives via salification with diethyl malonate or ethyl acetoacetate (or methyl ester) via Knoevenagel condensation reaction. The effects of three factors on the yield of synthetic coumarin-3-carboxylic acid ethyl ester were investigated. The results showed that the molar ratio of salicylaldehyde to malonic acid diester was 1:1.2 and the amount of K2CO3 was 0.1 mmol, and the reaction time is 15-18 min, the yield can reach 88.1%. When ethyl acetoacetate (or methyl ester) is used instead of diethyl malonate, 3-acetylcoumarin is obtained in a yield of 84.7% ( Or 82.9%); when the salicylaldehyde instead of the salicylaldehyde was substituted with diethyl malonate and ethyl acetoacetate (or methyl ester) respectively under the molar ratio of 1: 2.0, 8 The yield of 3-substituted coumarin derivatives was 62.5% -89.0% (or 58.1% -83.0%).