细胞因子信号抑制蛋白3(suppressor of cytokine signaling-3,SOCS-3)是一种常见的抑制性信号调节蛋白,参与负反馈调节Janus激酶/信号转导和转录激活因子(JAK/STAT)、促分裂素原活化蛋白激酶(MAPK)等多种重要信号通路,从而调控细胞因子、生长因子和激素对细胞的作用。细胞迁移和侵袭在一些生理过程和恶性肿瘤的发生发展中发挥了关键作用,SOCS-3可通过多种机制调节细胞的迁移及侵袭能力。 Suppressor of cytokine signaling-3 (SOCS-3) is a common inhibitory signal regulatory protein that is involved in the negative feedback regulation of Janus kinase / signal transducer and activator of transcription (JAK / STAT) Mitogen-activated protein kinase (MAPK) and many other important signaling pathways, thereby regulating the cytokines, growth factors and hormones on the cell. Cell migration and invasion play a key role in the development of some physiological processes and malignant tumors. SOCS-3 can regulate cell migration and invasion through a variety of mechanisms.