论文部分内容阅读
目的比较血清白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)及降钙素原(PCT)在重症手足口病合并细菌性脑炎诊断中的价值。方法回顾性分析2014年6月至2015年6月于本院就诊的110例重症手足口病合并脑炎患儿的临床资料,并按照最终出院诊断结果,分为重症手足口病合并细菌性脑炎组(A组,n=32)和重症手足口病合并病毒性脑炎组(B组,n=78)。检测两组患儿血清IL-6、hs-CRP及PCT水平,通过ROC分析法评估上述三项指标对疾病的诊断效能。结果 A组患儿血清IL-6、hs-CRP及PCT水平均高于B组,差异有统计学意义(P<0.05)。PCT的ROC曲线下面积为0.923,显著大于IL-6(0.801)及hs-CRP(0.794),且差异有统计学意义(P<0.05)。结论血清PCT检测诊断重症手足口病合并细菌性脑炎的临床诊断效能优于IL-6和hs-CRP,其是早期鉴别手足口病患儿是否合并细菌感染的敏感和可靠指标,值得推广应用。
Objective To compare the diagnostic value of serum interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in the diagnosis of severe hand-foot-mouth disease with bacterial encephalitis. Methods The clinical data of 110 cases of severe HFMD with encephalitis in our hospital from June 2014 to June 2015 were analyzed retrospectively. According to the final discharge diagnosis results, the patients were divided into severe HFMD complicated with bacterial brain Yan group (group A, n = 32) and severe HFMD group with viral encephalitis (group B, n = 78). Serum levels of IL-6, hs-CRP and PCT were detected in two groups of children, and the diagnostic efficacy of the above three indexes on the disease was evaluated by ROC analysis. Results The serum levels of IL-6, hs-CRP and PCT in group A were significantly higher than those in group B (P <0.05). The area under the ROC curve of PCT was 0.923, which was significantly higher than that of IL-6 (0.801) and hs-CRP (0.794), and the difference was statistically significant (P <0.05). Conclusion Serum PCT detection is superior to IL-6 and hs-CRP in the diagnosis of severe hand-foot-mouth disease complicated with bacterial encephalitis, which is a sensitive and reliable indicator of bacterial infections in early-stage HFMD patients. .