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Modulation by balancing activating and inhibitory receptors constitutes an important mechanism forregulating immune responses.Cells that are activated following ligation of receptors bearing immunoreceptortyrosine-based activation motifs (ITAMs) can be negatively regulated by other receptors bearing immuno-receptor tyrosine-based inhibition motifs (ITIMs).Human mast cells (MCs) are the major effector cells of typeⅠ hypersensitivity and important participants in a number of disease processes.Antigen-mediated aggregationof IgE bound to its high-affinity receptor on MCs initiates a complex series of biochemical events leading to MCactivation.With great detailed description and analysis of several inhibitory receptors on human MCs,acentral paradigm of negative regulation of human MC activation by these receptors has emerged.Cellular &Molecular Immunology.2004;1(6):408-415.
Modulation by balancing activator and inhibitory receptors an an important mechanism for regulatory immune responses. Cells that are activated following ligation of receptors bearing immunoreceptortyrosine-based activation motifs (ITAMs) can be negatively regulated by other receptor bearing immuno-receptor tyrosine-based inhibition motifs (ITIMs ). Human mast cells (MCs) are the major effector cells of type I hypersensitivity and important participants in a number of disease processes. Antigen-mediated aggregation of IgE bound to its high-affinity receptor on MCs initiates a complex series of biochemical events leading to MCactivation . With great detailed description and analysis of several inhibitory receptors on human MCs, acentral paradigm of negative regulation of human MC activation by these receptors has emerged. Cellular & Molecular Immunology. 2004; 1 (6): 408-415.