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用免疫放射技术（ＩＲＭＡ）对１２７例消化道癌肿病人与５２例正常对照组血清ＣＡ－５０进行检测，同时对９４例消化道癌肿病人及４０例正常对照组血清癌胚抗原（ＣＥＡ）进行放射免疫测定（ＲＩＡ），对ＣＡ－５０与ＣＥＡ的诊断价值进行了比较。结果表明，胰腺癌、壶腹癌、肝癌、胃癌、大肠癌的血清ＣＡ－５０均较对照组明显升高，差异均有显著性意义（Ｐ＜０．０１～０．０５），肝癌血清ＣＥＡ较对照组无显著升高（Ｐ＞０．０５）。ＣＡ－５０的ＩＲＭＡ的灵敏度较ＣＥＡ的ＲＩＡ明显升高，差异有显著性（Ｐ＜０．０５）。提示ＣＡ－５０的ＩＲＭＡ对消化道癌肿的诊断和鉴别有一定意义，其灵敏度优于ＣＥＡ的ＲＩＡ．
IRCA was used to detect CA-50 in 127 patients with digestive tract cancer and 52 normal controls. At the same time, serum carcinoembryonic antigen (CEA) was detected in 94 patients with gastrointestinal cancer and 40 normal controls. A radioimmunoassay (RIA) was performed to compare the diagnostic value of CA-50 with CEA. The results showed that the serum CA-50 levels in pancreatic cancer, ampullary carcinoma, liver cancer, gastric cancer and colorectal cancer were significantly higher than those in the control group (P<0.01 to 0.05). Compared with the control group, there was no significant increase (P>0.05). The sensitivity of IRMA of CA-50 was significantly higher than that of CEA, and the difference was significant (P<0.05). It is suggested that the IRMA of CA-50 has certain significance for the diagnosis and differential diagnosis of digestive tract cancer, and its sensitivity is better than that of CEA.