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探讨白细胞介素1β(IL-1β)对正常人甲状腺细胞(TEC)CD54、HLA-DR、CD80及凋亡率、凋亡蛋白Fas/FasL、基因FasmRNA表达的影响,结果提示IL-1β可以通过增加CD54和CD80的表达激活TEC呈递抗原,同时IL-1β可以轻度增加TEC的凋亡和凋亡蛋白的表达并显著增加碘促TEC凋亡作用。
To investigate the effect of interleukin-1β (IL-1β) on the expression of CD54, HLA-DR, CD80 and apoptosis in normal thyroid cells (TEC), the results showed that IL- Increasing the expressions of CD54 and CD80 activated the expression of TEC antigen, while IL-1β slightly increased the apoptosis of TEC and the expression of apoptotic protein, and significantly increased the apoptosis of iodine-induced TEC.