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在60年代初期开始广泛应用口服避孕药(oral contraceptive,简称OC),至今已20余年,1965年美国15～44岁已婚者约有15%应用OC,至1973年上升达25%(约660万人口),70年代中期达高峰,以后开始有下降趋势。但在其它国家使用者则仍持续上升。1977年估计全世界约有5,400万人用。1963年以来大量文献报道有关服OC的合并症,其中对心血管系统的影响主要表现为心肌梗塞、高血压、脑血管疾患及静脉血栓形成。在采用OC的早期,发现与心血管疾患的发病率有一定关系,曾使医师与使用者产生顾虑。因此复习有关文献,考虑有关因素,衡量其利弊作一综述介绍。在分析这些资料时要注意:①这些资料主要来源于英、美及北欧这些心血管疾患发病率较高的
In the early 1960s, oral contraceptives (OCs) were widely used for more than 20 years. In 1965, about 15% of US married couples aged 15-44 applied OC, up to 25% by 1973 (about 660 Million population) reached its peak in the mid-1970s and started to decline thereafter. However, users in other countries continued to rise. In 1977, an estimated 54 million people worldwide are using it. Since 1963 a large number of literature reports on the complications associated with OC, of which the main impact on the cardiovascular system, myocardial infarction, hypertension, cerebrovascular disease and venous thrombosis. In the early stages of using OC, we found that there was a certain relationship between the incidence of cardiovascular diseases and physicians and users. Therefore review the literature, consider the relevant factors, to measure the pros and cons for a review and introduction. In the analysis of these data should pay attention to: ① The information comes mainly from the United Kingdom, the United States and northern Europe, the higher incidence of cardiovascular disease